complementarity determining region การใช้

One end of the Ig domain has a section called the complementarity determining region that is important for the specificity of antibodies for their ligands.
A number of antibody proteins have RLR nests within the hairpin loops of their H-chain CDRs ( complementarity determining regions ) bound to a carboxylate side chain.
The complementarity determining regions of 5.11A1 were cloned into the framework of human IgG and combined with IgG1 ( TGN1112 ) or IgG4 ( TGN1412 ) constant regions.
Libraries of antibody Fab ( fragment, antigen binding ) regions were generated with codon substituted variations of the antibody complementarity determining regions ( CDRs ) inserted into human antibody light and heavy chain germline frameworks ( data on file at Mentrik Biotec ).
The molecule was genetically engineered by transfer of the complementarity determining regions ( CDRs ) from heavy and light chain variable region sequences of a monoclonal mouse anti-humanC28 [ sic ] antibody ( 5.11A1, Luhder et al ., 2003 ) into human heavy and light chain variable frameworks.